7mr8: Difference between revisions

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-'''Unreleased structure'''
-The entry 7mr8 is ON HOLD
+==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076==
+<StructureSection load='7mr8' size='340' side='right'caption='[[7mr8]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7mr8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MR8 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZNJ:N-{3-[(2-{3-fluoro-4-[(piperidin-4-yl)carbamoyl]anilino}-5-methylpyrimidin-4-yl)amino]-5-[(2-methylpropane-2-sulfonyl)amino]benzoyl}-L-glutamic+acid'>ZNJ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mr8 OCA], [https://pdbe.org/7mr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mr8 RCSB], [https://www.ebi.ac.uk/pdbsum/7mr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mr8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
-Authors: Chan, A., Schonbrunn, E.
+==See Also==
+*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
-Description: Crystal structure of the first bromodomain (BD1) of human BRD4 bound to GXH-II-076
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Schonbrunn, E]]
+__TOC__
-[[Category: Chan, A]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chan A]]
+[[Category: Schonbrunn E]]