7jh0: Difference between revisions

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-'''Unreleased structure'''
-The entry 7jh0 is ON HOLD
+==Crystallographic structure of glyceraldehyde-3-phosphate dehydrogenase from Schistosoma mansoni==
+<StructureSection load='7jh0' size='340' side='right'caption='[[7jh0]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7jh0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JH0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CSP:S-PHOSPHOCYSTEINE'>CSP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh0 OCA], [https://pdbe.org/7jh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jh0 RCSB], [https://www.ebi.ac.uk/pdbsum/7jh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/G3P_SCHMA G3P_SCHMA] This antigen is associated with human resistance to schistosomiasis.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The enzyme Glyceraldehyde-3-Phosphate Dehydrogenase from Schistosoma mansoni (SmGAPDH) is characterized as a therapeutical target for schistosomiasis. In this context, we report here the experimental structure, structural analyses and comparisons of SmGAPDH, the first one from a Platyhelminth. The enzyme was expressed, purified and assayed for crystallization, what allowed the obtainment of crystals of sufficient quality to collect X-ray diffraction data up to 2.51 A resolution. SmGAPDH is the only GAPDH to present the sequence NNR (its residues 114-116) which leads to (especially R116) a hydrogen bond network that possibly reflects on the flexibility of residues to interact with the adenine part of NAD(+), speculated to be important for differential drug design.
-Authors: Boreko, S., Silva, M., Iulek, J.
+Structure determination and analyses of the GAPDH from the parasite Schistosoma mansoni, the first one from a platyhelminth.,Boreiko S, Silva M, Iulek J Biochimie. 2021 May;184:18-25. doi: 10.1016/j.biochi.2021.01.014. Epub 2021 Jan , 30. PMID:33524435<ref>PMID:33524435</ref>
-Description: Structure and Analyses of the GAPDH from Schistosoma mansoni
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Silva, M]]
+<div class="pdbe-citations 7jh0" style="background-color:#fffaf0;"></div>
-[[Category: Boreko, S]]
-[[Category: Iulek, J]]
+==See Also==
+*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Schistosoma mansoni]]
+[[Category: Boreiko S]]
+[[Category: Iulek J]]
+[[Category: Silva M]]