5lc8: Difference between revisions

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OCA

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 ==Crystal Structure of specific mutant from Pseudomonas aeruginosa Lipoxygenase at 1.8A resolution==
-<StructureSection load='5lc8' size='340' side='right' caption='[[5lc8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='5lc8' size='340' side='right'caption='[[5lc8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5lc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LC8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5lc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LC8 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc8 OCA], [http://pdbe.org/5lc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc8 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lc8 OCA], [https://pdbe.org/5lc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lc8 RCSB], [https://www.ebi.ac.uk/pdbsum/5lc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lc8 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LOX_PSEAI LOX_PSEAI] In presence of oxygen, converts oleic acid into (S)-(E)-10-hydroperoxy-8-octadecenoic acid (HPOD), which spontaneously decomposes to the corresponding (E)-10-hydroxy-8-octadecenoic acid (HOD). In vivo, the reaction leads to the dihydroxy derivative (E)-7,10-dihydroxy-8-octadecenoic acid (DHOD), so that the three hydroxy-fatty acids can be isolated from the culture medium. Also active on linoleic acid and linolenic acid. Almost not active on arachidonic acid.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Banthiya, S]]
+[[Category: Large Structures]]
-[[Category: Kalms, J]]
+[[Category: Pseudomonas aeruginosa]]
-[[Category: Kuhn, H]]
+[[Category: Banthiya S]]
-[[Category: Scheerer, P]]
+[[Category: Galemou Yoga E]]
-[[Category: Yoga, E Galemou]]
+[[Category: Kalms J]]
-[[Category: A420g mutant]]
+[[Category: Kuhn H]]
-[[Category: Arachidonate 15s-lipoxygenase]]
+[[Category: Scheerer P]]
-[[Category: Eicosanoid]]
-[[Category: Infectious disease]]
-[[Category: Linoleate 13s-lipoxygenase]]
-[[Category: Non-heme iron enzyme]]
-[[Category: Oxidoreductase]]
-[[Category: Protein-phospholipid complex]]