6vg3: Difference between revisions
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==Structure of unliganded, inactive PTK7 kinase domain== | ==Structure of unliganded, inactive PTK7 kinase domain== | ||
<StructureSection load='6vg3' size='340' side='right'caption='[[6vg3]]' scene=''> | <StructureSection load='6vg3' size='340' side='right'caption='[[6vg3]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VG3 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6vg3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VG3 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vg3 OCA], [https://pdbe.org/6vg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6vg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vg3 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PTK7_HUMAN PTK7_HUMAN] Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.<ref>PMID:18471990</ref> <ref>PMID:20558616</ref> <ref>PMID:20837484</ref> <ref>PMID:21103379</ref> <ref>PMID:21132015</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lemmon MA]] | [[Category: Lemmon MA]] | ||