6ucd: Difference between revisions

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'''Unreleased structure'''


The entry 6ucd is ON HOLD  until Paper Publication
==The crystal structure of Staphylococcus aureus super antigen-like protein SSL10==
<StructureSection load='6ucd' size='340' side='right'caption='[[6ucd]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ucd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ucd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucd OCA], [https://pdbe.org/6ucd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ucd RCSB], [https://www.ebi.ac.uk/pdbsum/6ucd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSL10_STAA8 SSL10_STAA8] Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).<ref>PMID:19308288</ref> <ref>PMID:19913916</ref> <ref>PMID:23754290</ref> <ref>PMID:28193526</ref>


Authors: Patel, D., Young, P.G., Bunker, R.D., Baker, E.N., Fraser, J.D.
==See Also==
 
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
Description: The crystal structure of Staphylococcus aureus super antigen-like protein SSL10
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Fraser, J.D]]
__TOC__
[[Category: Bunker, R.D]]
</StructureSection>
[[Category: Baker, E.N]]
[[Category: Large Structures]]
[[Category: Patel, D]]
[[Category: Staphylococcus aureus]]
[[Category: Young, P.G]]
[[Category: Baker EN]]
[[Category: Bunker RD]]
[[Category: Fraser JD]]
[[Category: Patel D]]
[[Category: Young PG]]

Latest revision as of 10:49, 11 October 2023

The crystal structure of Staphylococcus aureus super antigen-like protein SSL10The crystal structure of Staphylococcus aureus super antigen-like protein SSL10

Structural highlights

6ucd is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.85Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SSL10_STAA8 Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).[1] [2] [3] [4]

See Also

References

  1. ↑ Walenkamp AM, Boer IG, Bestebroer J, Rozeveld D, Timmer-Bosscha H, Hemrika W, van Strijp JA, de Haas CJ. Staphylococcal superantigen-like 10 inhibits CXCL12-induced human tumor cell migration. Neoplasia. 2009 Apr;11(4):333-44. PMID:19308288 doi:10.1593/neo.81508
  2. ↑ Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T. Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway. Mol Immunol. 2010 Jan;47(4):932-8. PMID:19913916 doi:10.1016/j.molimm.2009.09.027
  3. ↑ Itoh S, Yokoyama R, Kamoshida G, Fujiwara T, Okada H, Takii T, Tsuji T, Fujii S, Hashizume H, Onozaki K. Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain. J Biol Chem. 2013 Jul 26;288(30):21569-80. PMID:23754290 doi:10.1074/jbc.M113.451419
  4. ↑ Itoh S, Takii T, Onozaki K, Tsuji T, Hida S. Identification of the blood coagulation factor interacting sequences in staphylococcal superantigen-like protein 10. Biochem Biophys Res Commun. 2017 Mar 25;485(1):201-208. PMID:28193526 doi:10.1016/j.bbrc.2017.02.053

6ucd, resolution 2.85Å

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