6ucd: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ucd is ON HOLD
+==The crystal structure of Staphylococcus aureus super antigen-like protein SSL10==
+<StructureSection load='6ucd' size='340' side='right'caption='[[6ucd]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ucd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UCD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ucd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ucd OCA], [https://pdbe.org/6ucd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ucd RCSB], [https://www.ebi.ac.uk/pdbsum/6ucd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ucd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SSL10_STAA8 SSL10_STAA8] Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction (PubMed:19913916). Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin (PubMed:23754290, PubMed:28193526). Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration (PubMed:19308288).<ref>PMID:19308288</ref> <ref>PMID:19913916</ref> <ref>PMID:23754290</ref> <ref>PMID:28193526</ref>
-Authors: Patel, D., Young, P.G., Bunker, R.D., Baker, E.N., Fraser, J.D.
+==See Also==
+*[[Exotoxin 3D structures|Exotoxin 3D structures]]
-Description: The crystal structure of Staphylococcus aureus super antigen-like protein SSL10
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Fraser, J.D]]
+__TOC__
-[[Category: Bunker, R.D]]
+</StructureSection>
-[[Category: Baker, E.N]]
+[[Category: Large Structures]]
-[[Category: Patel, D]]
+[[Category: Staphylococcus aureus]]
-[[Category: Young, P.G]]
+[[Category: Baker EN]]
+[[Category: Bunker RD]]
+[[Category: Fraser JD]]
+[[Category: Patel D]]
+[[Category: Young PG]]