6p2a: Difference between revisions

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'''Unreleased structure'''


The entry 6p2a is ON HOLD  until Paper Publication
==Chimera of bacteriophage OBP gp146 central spike protein and a T4 gp5 beta-helix fragment==
 
<StructureSection load='6p2a' size='340' side='right'caption='[[6p2a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Buth, S.A., Shneider, M.M., Leiman, P.G.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6p2a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Pseudomonas_phage_OBP Pseudomonas phage OBP]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P2A FirstGlance]. <br>
Description: Chimera of bacteriophage OBP gp146 central spike protein and a T4 gp5 beta-helix fragment
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ELA:9-OCTADECENOIC+ACID'>ELA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=STE:STEARIC+ACID'>STE</scene></td></tr>
[[Category: Leiman, P.G]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p2a OCA], [https://pdbe.org/6p2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p2a RCSB], [https://www.ebi.ac.uk/pdbsum/6p2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p2a ProSAT]</span></td></tr>
[[Category: Shneider, M.M]]
</table>
[[Category: Buth, S.A]]
== Function ==
[https://www.uniprot.org/uniprot/G9IA38_9CAUD G9IA38_9CAUD] [https://www.uniprot.org/uniprot/NEEDL_BPT4 NEEDL_BPT4] Tail-associated lysozyme of the baseplate hub that is essential for localized hydrolysis of bacterial cell wall necessary for viral DNA injection. The needle-like gp5 protein punctures the outer cell membrane and then digests the peptidoglycan cell wall in the periplasmic space. Involved in the tail assembly.<ref>PMID:12837775</ref> <ref>PMID:21129200</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Pseudomonas phage OBP]]
[[Category: Buth SA]]
[[Category: Leiman PG]]
[[Category: Shneider MM]]

Latest revision as of 10:21, 11 October 2023

Chimera of bacteriophage OBP gp146 central spike protein and a T4 gp5 beta-helix fragmentChimera of bacteriophage OBP gp146 central spike protein and a T4 gp5 beta-helix fragment

Structural highlights

6p2a is a 6 chain structure with sequence from Escherichia virus T4 and Pseudomonas phage OBP. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G9IA38_9CAUD NEEDL_BPT4 Tail-associated lysozyme of the baseplate hub that is essential for localized hydrolysis of bacterial cell wall necessary for viral DNA injection. The needle-like gp5 protein punctures the outer cell membrane and then digests the peptidoglycan cell wall in the periplasmic space. Involved in the tail assembly.[1] [2]

References

  1. ↑ Weigele PR, Scanlon E, King J. Homotrimeric, beta-stranded viral adhesins and tail proteins. J Bacteriol. 2003 Jul;185(14):4022-30. PMID:12837775
  2. ↑ Leiman PG, Arisaka F, van Raaij MJ, Kostyuchenko VA, Aksyuk AA, Kanamaru S, Rossmann MG. Morphogenesis of the T4 tail and tail fibers. Virol J. 2010 Dec 3;7:355. doi: 10.1186/1743-422X-7-355. PMID:21129200 doi:10.1186/1743-422X-7-355

6p2a, resolution 1.90Å

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