6opl: Difference between revisions
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==Human biliverdin IX beta reductase Q14R mutant: NADP complex== | |||
<StructureSection load='6opl' size='340' side='right'caption='[[6opl]], [[Resolution|resolution]] 1.37Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6opl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OPL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6opl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6opl OCA], [https://pdbe.org/6opl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6opl RCSB], [https://www.ebi.ac.uk/pdbsum/6opl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6opl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref> | |||
==See Also== | |||
*[[Flavin reductase|Flavin reductase]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Eisenmesser | __TOC__ | ||
[[Category: Paukovich | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Eisenmesser EZ]] | |||
[[Category: Paukovich NA]] | |||
Latest revision as of 10:14, 11 October 2023
Human biliverdin IX beta reductase Q14R mutant: NADP complexHuman biliverdin IX beta reductase Q14R mutant: NADP complex
Structural highlights
FunctionBLVRB_HUMAN Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.[1] See AlsoReferences |
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