6oda: Difference between revisions

<table><tr><td colspan='2'>[[6oda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ODA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C7:2-(4-CHLOROPHENYL)-4-[(3S)-PIPERIDIN-3-YLAMINO]THIENO[2,3-D]PYRIDAZINE-7-CARBOXAMIDE'>C7</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oda OCA], [https://pdbe.org/6oda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oda RCSB], [https://www.ebi.ac.uk/pdbsum/6oda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oda ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>  

 

[[Category: Homo sapiens]]

[[Category: Bair K]]

[[Category: Barczak N]]

[[Category: Caravella J]]

[[Category: Conti C]]

[[Category: Garcia-Dancey R]]

[[Category: Han B]]

[[Category: Hardy C]]

[[Category: Lahdenranta J]]

[[Category: Lancia Jr D]]

[[Category: Leng C]]

[[Category: Li P]]

[[Category: Liu C]]

[[Category: Martin M]]

[[Category: Ng PY]]

[[Category: Pardo E]]

[[Category: Rudnitskaya A]]

[[Category: Saldahna A]]

[[Category: Tan T]]

[[Category: Thomason JJ]]

[[Category: Toms AV]]

[[Category: Yao L]]

[[Category: Zablocki M-M]]

[[Category: Zhang C]]

[[Category: Zheng X]]