6nf7: Difference between revisions
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==Crystal Structure of RT1.Aa-Bu31-10== | |||
<StructureSection load='6nf7' size='340' side='right'caption='[[6nf7]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nf7]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NF7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nf7 OCA], [https://pdbe.org/6nf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nf7 RCSB], [https://www.ebi.ac.uk/pdbsum/6nf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nf7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HA12_RAT HA12_RAT] Involved in the presentation of foreign antigens to the immune system. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
To reduce the use of non-specific immunosuppressive drugs detrimental to transplant patient health, therapies in development aim to achieve antigen-specific tolerance by promoting antigen-specific regulatory T cells (Tregs). However, identification of the natural antigens recognized by Tregs and the contribution of their dominance in transplantation has been challenging. We identify epitopes derived from distinct major histocompatibility complex (MHC) class II molecules, sharing a 7-amino acid consensus sequence positioned in a central mobile section in complex with MHC class I, recognized by cross-reactive CD8(+) Tregs, enriched in the graft. Antigen-specific CD8(+) Tregs can be induced in vivo with a 16-amino acid-long peptide to trigger transplant tolerance. Peptides derived from human HLA class II molecules, harboring the rat consensus sequence, also activate and expand human CD8(+) Tregs, suggesting its potential in human transplantation. Altogether, this work should facilitate the development of therapies with peptide epitopes for transplantation and improve our understanding of CD8(+) Treg recognition. | |||
Cross-Reactive Donor-Specific CD8(+) Tregs Efficiently Prevent Transplant Rejection.,Picarda E, Bezie S, Usero L, Ossart J, Besnard M, Halim H, Echasserieau K, Usal C, Rossjohn J, Bernardeau K, Gras S, Guillonneau C Cell Rep. 2019 Dec 24;29(13):4245-4255.e6. doi: 10.1016/j.celrep.2019.11.106. PMID:31875536<ref>PMID:31875536</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6nf7" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Gras S]] | |||
Latest revision as of 09:52, 11 October 2023
Crystal Structure of RT1.Aa-Bu31-10Crystal Structure of RT1.Aa-Bu31-10
Structural highlights
FunctionHA12_RAT Involved in the presentation of foreign antigens to the immune system. Publication Abstract from PubMedTo reduce the use of non-specific immunosuppressive drugs detrimental to transplant patient health, therapies in development aim to achieve antigen-specific tolerance by promoting antigen-specific regulatory T cells (Tregs). However, identification of the natural antigens recognized by Tregs and the contribution of their dominance in transplantation has been challenging. We identify epitopes derived from distinct major histocompatibility complex (MHC) class II molecules, sharing a 7-amino acid consensus sequence positioned in a central mobile section in complex with MHC class I, recognized by cross-reactive CD8(+) Tregs, enriched in the graft. Antigen-specific CD8(+) Tregs can be induced in vivo with a 16-amino acid-long peptide to trigger transplant tolerance. Peptides derived from human HLA class II molecules, harboring the rat consensus sequence, also activate and expand human CD8(+) Tregs, suggesting its potential in human transplantation. Altogether, this work should facilitate the development of therapies with peptide epitopes for transplantation and improve our understanding of CD8(+) Treg recognition. Cross-Reactive Donor-Specific CD8(+) Tregs Efficiently Prevent Transplant Rejection.,Picarda E, Bezie S, Usero L, Ossart J, Besnard M, Halim H, Echasserieau K, Usal C, Rossjohn J, Bernardeau K, Gras S, Guillonneau C Cell Rep. 2019 Dec 24;29(13):4245-4255.e6. doi: 10.1016/j.celrep.2019.11.106. PMID:31875536[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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