6ndh: Difference between revisions

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'''Unreleased structure'''


The entry 6ndh is ON HOLD
==RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND ZINC==
<StructureSection load='6ndh' size='340' side='right'caption='[[6ndh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ndh]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NDH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ndh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ndh OCA], [https://pdbe.org/6ndh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ndh RCSB], [https://www.ebi.ac.uk/pdbsum/6ndh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ndh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLEC_CALRH SLEC_CALRH] Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.<ref>PMID:11121411</ref> <ref>PMID:12871211</ref>


Authors: Stetefeld, J., McDougall, M.D., Loewen, P.C.
==See Also==
 
*[[Integrin 3D structures|Integrin 3D structures]]
Description: RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN WITH ZINC BOUND
*[[Rhodocetin|Rhodocetin]]
[[Category: Unreleased Structures]]
== References ==
[[Category: Stetefeld, J]]
<references/>
[[Category: Loewen, P.C]]
__TOC__
[[Category: Mcdougall, M.D]]
</StructureSection>
[[Category: Calloselasma rhodostoma]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Loewen PC]]
[[Category: McDougall MD]]
[[Category: Stetefeld J]]

Latest revision as of 09:51, 11 October 2023

RHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND ZINCRHODOCETIN IN COMPLEX WITH THE INTEGRIN ALPHA2-A DOMAIN AND ZINC

Structural highlights

6ndh is a 18 chain structure with sequence from Calloselasma rhodostoma and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SLEC_CALRH Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.[1] [2]

See Also

References

  1. ↑ Eble JA, Beermann B, Hinz HJ, Schmidt-Hederich A. alpha 2beta 1 integrin is not recognized by rhodocytin but is the specific, high affinity target of rhodocetin, an RGD-independent disintegrin and potent inhibitor of cell adhesion to collagen. J Biol Chem. 2001 Apr 13;276(15):12274-84. Epub 2000 Dec 19. PMID:11121411 doi:http://dx.doi.org/10.1074/jbc.M009338200
  2. ↑ Eble JA, Tuckwell DS. The alpha2beta1 integrin inhibitor rhodocetin binds to the A-domain of the integrin alpha2 subunit proximal to the collagen-binding site. Biochem J. 2003 Nov 15;376(Pt 1):77-85. PMID:12871211 doi:http://dx.doi.org/10.1042/BJ20030373

6ndh, resolution 2.90Å

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