6mkr: Difference between revisions

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 <StructureSection load='6mkr' size='340' side='right'caption='[[6mkr]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6mkr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MKR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6mkr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MKR FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mkd|6mkd]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.355&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-arginine_deiminase Protein-arginine deiminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.15 3.5.3.15] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mkr OCA], [https://pdbe.org/6mkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mkr RCSB], [https://www.ebi.ac.uk/pdbsum/6mkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mkr ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mkr OCA], [http://pdbe.org/6mkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mkr RCSB], [http://www.ebi.ac.uk/pdbsum/6mkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mkr ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PADI4_MOUSE PADI4_MOUSE]] Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.<ref>PMID:15339660</ref> <ref>PMID:20733033</ref> <ref>PMID:23650392</ref> <ref>PMID:24463520</ref>
+[https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 18: @@
 </div>
 <div class="pdbe-citations 6mkr" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[MHC 3D structures|MHC 3D structures]]
+*[[MHC II 3D structures|MHC II 3D structures]]
 == References ==
 <references/>
@@ Line 24: / Line 27: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Protein-arginine deiminase]]
+[[Category: Mus musculus]]
-[[Category: Blevins, S J]]
+[[Category: Blevins SJ]]
-[[Category: Huseby, E S]]
+[[Category: Huseby ES]]
-[[Category: Stadinski, B D]]
+[[Category: Stadinski BD]]
-[[Category: Immune system]]
-[[Category: Major histocompatibility complex]]
-[[Category: T cell receptor]]