6me5: Difference between revisions

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<StructureSection load='6me5' size='340' side='right'caption='[[6me5]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='6me5' size='340' side='right'caption='[[6me5]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6me5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ME5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6me5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ME5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AWY:~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide'>AWY</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWY:~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide'>AWY</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTNR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6me5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me5 OCA], [https://pdbe.org/6me5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6me5 RCSB], [https://www.ebi.ac.uk/pdbsum/6me5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6me5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6me5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me5 OCA], [http://pdbe.org/6me5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6me5 RCSB], [http://www.ebi.ac.uk/pdbsum/6me5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6me5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.  
[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Batyuk, A]]
[[Category: Pyrococcus abyssi GE5]]
[[Category: Brehm, W]]
[[Category: Batyuk A]]
[[Category: Cherezov, V]]
[[Category: Brehm W]]
[[Category: Gati, C]]
[[Category: Cherezov V]]
[[Category: Grandner, J M]]
[[Category: Gati C]]
[[Category: Grant, T D]]
[[Category: Grandner JM]]
[[Category: Han, G W]]
[[Category: Grant TD]]
[[Category: Ishchenko, A]]
[[Category: Han GW]]
[[Category: Johansson, L C]]
[[Category: Ishchenko A]]
[[Category: Katritch, V]]
[[Category: Johansson LC]]
[[Category: Liu, W]]
[[Category: Katritch V]]
[[Category: Madsen, C]]
[[Category: Liu W]]
[[Category: McCorvy, J D]]
[[Category: Madsen C]]
[[Category: Michaelian, N]]
[[Category: McCorvy JD]]
[[Category: Olsen, R H.J]]
[[Category: Michaelian N]]
[[Category: Patel, N]]
[[Category: Olsen RHJ]]
[[Category: Roth, B L]]
[[Category: Patel N]]
[[Category: Stauch, B]]
[[Category: Roth BL]]
[[Category: Tribo, A R]]
[[Category: Stauch B]]
[[Category: Weierstall, U]]
[[Category: Tribo AR]]
[[Category: White, T A]]
[[Category: Weierstall U]]
[[Category: Zhu, L]]
[[Category: White TA]]
[[Category: Agomelatine]]
[[Category: Zhu L]]
[[Category: Circadian rhythm]]
[[Category: Gpcr]]
[[Category: Jetlag]]
[[Category: Lcp]]
[[Category: Membrane protein]]
[[Category: Pg]]
[[Category: Xfel]]

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