6dvr: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6dvr is ON HOLD
+==Crystal structure of human CARM1 with (R)-SKI-72==
+<StructureSection load='6dvr' size='340' side='right'caption='[[6dvr]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6dvr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DVR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HDG:(2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide+(non-preferred+name)'>HDG</scene>, <scene name='pdbligand=P15:2,5,8,11,14,17-HEXAOXANONADECAN-19-OL'>P15</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dvr OCA], [https://pdbe.org/6dvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dvr RCSB], [https://www.ebi.ac.uk/pdbsum/6dvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dvr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CARM1_HUMAN CARM1_HUMAN] Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.<ref>PMID:16497732</ref> <ref>PMID:19405910</ref>
-Authors: Dong, A., Zeng, H., Hutchinson, A., Seitova, A., Luo, M., Cai, X.C., Ke, W., Wang, J., Shi, C., Zheng, W., Lee, J.P., Ibanez, G., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
-Description: Crystal structure of human CARM1 with (R)-SKI-72
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Hutchinson, A]]
+__TOC__
-[[Category: Ke, W]]
+</StructureSection>
-[[Category: Ibanez, G]]
+[[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.H]]
+[[Category: Large Structures]]
-[[Category: Seitova, A]]
+[[Category: Arrowsmith CH]]
-[[Category: Dong, A]]
+[[Category: Bountra C]]
-[[Category: Lee, J.P]]
+[[Category: Brown PJ]]
-[[Category: Luo, M]]
+[[Category: Cai XC]]
-[[Category: Brown, P.J]]
+[[Category: Dong A]]
-[[Category: Zeng, H]]
+[[Category: Edwards AM]]
-[[Category: Shi, C]]
+[[Category: Hutchinson A]]
-[[Category: Cai, X.C]]
+[[Category: Ibanez G]]
-[[Category: Edwards, A.M]]
+[[Category: Ke W]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Lee JP]]
-[[Category: Wang, J]]
+[[Category: Luo M]]
-[[Category: Zheng, W]]
+[[Category: Seitova A]]
-[[Category: Bountra, C]]
+[[Category: Shi C]]
+[[Category: Wang J]]
+[[Category: Zeng H]]
+[[Category: Zheng W]]