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==Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23)== | |||
<StructureSection load='6diq' size='340' side='right'caption='[[6diq]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6diq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DIQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.579Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GK7:methyl+[(2S)-1-{[(2R,6S,12Z,13aS,14aR,16aS)-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-14a-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]amino}-3,3-dimethyl-1-oxobutan-2-yl]carbamate'>GK7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6diq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6diq OCA], [https://pdbe.org/6diq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6diq RCSB], [https://www.ebi.ac.uk/pdbsum/6diq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6diq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0B4WYC6_9HEPC A0A0B4WYC6_9HEPC] | |||
==See Also== | |||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Matthew | [[Category: Hepacivirus C]] | ||
[[Category: Schiffer | [[Category: Large Structures]] | ||
[[Category: Matthew AN]] | |||
[[Category: Schiffer CA]] | |||
Latest revision as of 09:07, 11 October 2023
Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23)Crystal structure of HCV NS3/4A protease in complex with P4-P5-1 (WK-23)
Structural highlights
FunctionSee Also |
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