6dch: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='6dch' size='340' side='right'caption='[[6dch]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6dch' size='340' side='right'caption='[[6dch]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6dch]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6dch]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coeruleorubidus Streptomyces coeruleorubidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DCH FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dch OCA], [https://pdbe.org/6dch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dch RCSB], [https://www.ebi.ac.uk/pdbsum/6dch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dch ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A3B6UEU3_STRC4 A0A3B6UEU3_STRC4] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Streptomyces coeruleorubidus]] | ||
[[Category: | [[Category: Born DA]] | ||
[[Category: | [[Category: Drennan CL]] | ||
Latest revision as of 09:02, 11 October 2023
Structure of isonitrile biosynthesis enzyme ScoEStructure of isonitrile biosynthesis enzyme ScoE
Structural highlights
FunctionPublication Abstract from PubMedThe electron-rich isonitrile is an important functionality in bioactive natural products, but its biosynthesis has been restricted to the IsnA family of isonitrile synthases. We here provide the first structural and biochemical evidence of an alternative mechanism for isonitrile formation. ScoE, a putative non-heme iron(II)-dependent enzyme from Streptomyces coeruleorubidus, was shown to catalyze the conversion of (R)-3-((carboxymethyl)amino)butanoic acid to (R)-3-isocyanobutanoic acid through an oxidative decarboxylation mechanism. This work further provides a revised scheme for the biosynthesis of a unique class of isonitrile lipopeptides, members of which are critical for the virulence of pathogenic mycobacteria. Isonitrile Formation by a Non-heme Iron(II)-Dependent Oxidase/Decarboxylase.,Harris N, Born D, Cai W, Huang Y, Martin J, Khalaf R, Drennan C, Zhang W Angew Chem Int Ed Engl. 2018 Jun 15. doi: 10.1002/anie.201804307. PMID:29906336[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
|
| ||||||||||||||||||