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==Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.==
==Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.==
<StructureSection load='5lba' size='340' side='right' caption='[[5lba]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5lba' size='340' side='right'caption='[[5lba]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5lba]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LBA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5lba]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LBA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6SV:1-CYCLOHEXYL-3-[[(2~{R})-OXOLAN-2-YL]METHYL]UREA'>6SV</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SV:1-CYCLOHEXYL-3-[[(2~{R})-OXOLAN-2-YL]METHYL]UREA'>6SV</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lba OCA], [http://pdbe.org/5lba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lba RCSB], [http://www.ebi.ac.uk/pdbsum/5lba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lba ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lba OCA], [https://pdbe.org/5lba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lba RCSB], [https://www.ebi.ac.uk/pdbsum/5lba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lba ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RECQ5_HUMAN RECQ5_HUMAN]] May have an important role in DNA metabolism.  
[https://www.uniprot.org/uniprot/RECQ5_HUMAN RECQ5_HUMAN] May have an important role in DNA metabolism.
 
==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA helicase]]
[[Category: Homo sapiens]]
[[Category: Aitkenhead, H]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Aitkenhead H]]
[[Category: Bountra, C]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F Von]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Gileadi, O]]
[[Category: Gileadi O]]
[[Category: Krojer, T]]
[[Category: Krojer T]]
[[Category: Newman, J A]]
[[Category: Newman JA]]
[[Category: Structural genomic]]
[[Category: Savitsky P]]
[[Category: Savitsky, P]]
[[Category: Talon R]]
[[Category: Talon, R]]
[[Category: Von Delft F]]
[[Category: Diamond i04-1 xchem]]
[[Category: Fragment screening]]
[[Category: Helicase]]
[[Category: Hydrolase]]
[[Category: Recq]]
[[Category: Sgc]]
[[Category: Transcription]]

Latest revision as of 19:13, 4 October 2023

Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.Crystal structure of human RECQL5 helicase in complex with DSPL fragment(1-cyclohexyl-3-(oxolan-2-ylmethyl)urea, SGC - Diamond XChem I04-1 fragment screening.

Structural highlights

5lba is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RECQ5_HUMAN May have an important role in DNA metabolism.

See Also

5lba, resolution 2.50Å

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OCA
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