3auf: Difference between revisions

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-'''Unreleased structure'''
-The entry 3auf is ON HOLD  until Paper Publication
+==Crystal structure of glycinamide ribonucleotide transformylase 1 from Symbiobacterium toebii==
+<StructureSection load='3auf' size='340' side='right'caption='[[3auf]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3auf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Symbiobacterium_toebii Symbiobacterium toebii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AUF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3auf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3auf OCA], [https://pdbe.org/3auf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3auf RCSB], [https://www.ebi.ac.uk/pdbsum/3auf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3auf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/E5RXD0_9FIRM E5RXD0_9FIRM]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The crystal structures of glycinamide ribonucleotide transformylases (PurNs) from Aquifex aeolicus (Aa), Geobacillus kaustophilus (Gk) and Symbiobacterium toebii (St), and of formyltetrahydrofolate hydrolase (PurU) from Thermus thermophilus (Tt) were determined. The monomer structures of the determined PurN and PurU were very similar to the known structure of PurN, but oligomeric states were different; AaPurN and StPurN formed dimers, GkPurN formed monomer and PurU formed tetramer in the crystals. PurU had a regulatory ACT domain in its N-terminal side. So far several structures of PurUs have been determined, yet, the mechanisms of the catalysis and the regulation of PurU have not been elucidated. We, therefore, modelled ligand-bound structures of PurN and PurU, and performed molecular dynamics simulations to elucidate the reaction mechanisms. The evolutionary relationship of the two enzymes is discussed based on the comparisons of the structures and the catalytic mechanisms.
-Authors: Kanagawa, M., Baba, S., Nagira, T., Kuramitsu, S., Yokoyama, S., Sampei, G., Kawai, G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
+Structures and reaction mechanisms of the two related enzymes, PurN and PurU.,Sampei G, Kanagawa M, Baba S, Shimasaki T, Taka H, Mitsui S, Fujiwara S, Yanagida Y, Kusano M, Suzuki S, Terao K, Kawai H, Fukai Y, Nakagawa N, Ebihara A, Kuramitsu S, Yokoyama S, Kawai G J Biochem. 2013 Dec;154(6):569-79. doi: 10.1093/jb/mvt090. Epub 2013 Oct 9. PMID:24108189<ref>PMID:24108189</ref>
-Description: Crystal structure of glycinamide ribonucleotide transformylase 1 from Symbiobacterium toebii
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3auf" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Symbiobacterium toebii]]
+[[Category: Baba S]]
+[[Category: Kanagawa M]]
+[[Category: Kawai G]]
+[[Category: Kuramitsu S]]
+[[Category: Nagira T]]
+[[Category: Sampei G]]
+[[Category: Yokoyama S]]