6d3l: Difference between revisions

<table><tr><td colspan='2'>[[6d3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D3L FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3l OCA], [https://pdbe.org/6d3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d3l RCSB], [https://www.ebi.ac.uk/pdbsum/6d3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3l ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/E2AK2_HUMAN E2AK2_HUMAN] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.<ref>PMID:20395957</ref>  

[[Category: Cole JL]]

[[Category: Erlandsen H]]

[[Category: Mayo C]]

[[Category: Robinson VL]]