6cin: Difference between revisions

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 ==Crystal structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica==
-<StructureSection load='6cin' size='340' side='right' caption='[[6cin]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='6cin' size='340' side='right'caption='[[6cin]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6cin]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Moota Moota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CIN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6cin]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CIN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[d_1000232406|d_1000232406]], [[d_1000232407|d_1000232407]], [[d_1000232408|d_1000232408]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Moth_0064 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cin OCA], [https://pdbe.org/6cin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cin RCSB], [https://www.ebi.ac.uk/pdbsum/6cin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cin ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cin OCA], [http://pdbe.org/6cin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cin RCSB], [http://www.ebi.ac.uk/pdbsum/6cin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cin ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/Q2RMD6_MOOTA Q2RMD6_MOOTA]] Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.[PIRNR:PIRNR000159]
+[https://www.uniprot.org/uniprot/PFOR_MOOTA PFOR_MOOTA] Catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA and carbon dioxide. The two electrons that are generated as a result of pyruvate decarboxylation are used in the reduction of low potential ferredoxins, which provide reducing equivalents for central metabolism. Also catalyzes the reverse reaction, i.e. the synthesis of pyruvate from acetyl-CoA and carbon dioxide. Appears to function physiologically in both directions (PubMed:10878009). The oxidation of pyruvate by PFOR is required to connect glycolysis and the Wood-Ljungdahl pathway of reductive acetogenesis. The conversion of acetyl-CoA to pyruvate links the Wood-Ljungdahl pathway of autotrophic CO2 fixation to the reductive tricarboxylic acid cycle (PubMed:10878009, PubMed:29581263). Can use methyl viologen as electron carrier in vitro (PubMed:9214293, PubMed:29581263).<ref>PMID:10878009</ref> <ref>PMID:29581263</ref> <ref>PMID:9214293</ref> <ref>PMID:10878009</ref> <ref>PMID:29581263</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 </div>
 <div class="pdbe-citations 6cin" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Pyruvate-ferredoxin oxidoreductase|Pyruvate-ferredoxin oxidoreductase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Moota]]
+[[Category: Large Structures]]
-[[Category: Chen, P Y.T]]
+[[Category: Moorella thermoacetica ATCC 39073]]
-[[Category: Drennan, C L]]
+[[Category: Chen PY-T]]
-[[Category: Coenzyme some]]
+[[Category: Drennan CL]]
-[[Category: Gated electron transfer]]
-[[Category: Oxidoreductase]]
-[[Category: Pyruvate:ferredoxin oxidoreductase]]
-[[Category: Thiamine pyrophosphate]]