6cd6: Difference between revisions

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'''Unreleased structure'''


The entry 6cd6 is ON HOLD
==Crystal Structure of the Human CAMKK1A in complex with GSK650394==
<StructureSection load='6cd6' size='340' side='right'caption='[[6cd6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6cd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CD6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cd6 OCA], [https://pdbe.org/6cd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cd6 RCSB], [https://www.ebi.ac.uk/pdbsum/6cd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cd6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>


Authors: Santiago, A.S., Counago, R.M., Righetto, G.L., Ramos, P.Z., Silva, P.N.B., Drewry, D., Elkins, J.M., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
Description: Crystal Structure of the Human CAMKK1A in complex with GSK650394
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Righetto, G.L]]
__TOC__
[[Category: Elkins, J.M]]
</StructureSection>
[[Category: Massirer, K.B]]
[[Category: Homo sapiens]]
[[Category: Counago, R.M]]
[[Category: Large Structures]]
[[Category: Drewry, D]]
[[Category: Arruda P]]
[[Category: Edwards, A.M]]
[[Category: Counago RM]]
[[Category: Silva, P.N.B]]
[[Category: Drewry D]]
[[Category: Arruda, P]]
[[Category: Edwards AM]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Elkins JM]]
[[Category: Santiago, A.S]]
[[Category: Massirer KB]]
[[Category: Ramos, P.Z]]
[[Category: Ramos PZ]]
[[Category: Righetto GL]]
[[Category: Santiago AS]]
[[Category: Silva PNB]]

Latest revision as of 18:01, 4 October 2023

Crystal Structure of the Human CAMKK1A in complex with GSK650394Crystal Structure of the Human CAMKK1A in complex with GSK650394

Structural highlights

6cd6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KKCC1_HUMAN Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.[1]

See Also

References

  1. ↑ Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003 Aug 28;550(1-3):57-63. PMID:12935886

6cd6, resolution 2.20Å

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