6cd6: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 6cd6 is ON HOLD
+==Crystal Structure of the Human CAMKK1A in complex with GSK650394==
+<StructureSection load='6cd6' size='340' side='right'caption='[[6cd6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6cd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CD6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cd6 OCA], [https://pdbe.org/6cd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cd6 RCSB], [https://www.ebi.ac.uk/pdbsum/6cd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cd6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref>
-Authors: Santiago, A.S., Counago, R.M., Righetto, G.L., Ramos, P.Z., Silva, P.N.B., Drewry, D., Elkins, J.M., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC)
+==See Also==
+*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
-Description: Crystal Structure of the Human CAMKK1A in complex with GSK650394
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Righetto, G.L]]
+__TOC__
-[[Category: Elkins, J.M]]
+</StructureSection>
-[[Category: Massirer, K.B]]
+[[Category: Homo sapiens]]
-[[Category: Counago, R.M]]
+[[Category: Large Structures]]
-[[Category: Drewry, D]]
+[[Category: Arruda P]]
-[[Category: Edwards, A.M]]
+[[Category: Counago RM]]
-[[Category: Silva, P.N.B]]
+[[Category: Drewry D]]
-[[Category: Arruda, P]]
+[[Category: Edwards AM]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Elkins JM]]
-[[Category: Santiago, A.S]]
+[[Category: Massirer KB]]
-[[Category: Ramos, P.Z]]
+[[Category: Ramos PZ]]
+[[Category: Righetto GL]]
+[[Category: Santiago AS]]
+[[Category: Silva PNB]]