6c9t: Difference between revisions

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-'''Unreleased structure'''
-The entry 6c9t is ON HOLD
+==Transcriptional repressor, CouR==
+<StructureSection load='6c9t' size='340' side='right'caption='[[6c9t]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_CGA009 Rhodopseudomonas palustris CGA009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C9T FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c9t OCA], [https://pdbe.org/6c9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c9t RCSB], [https://www.ebi.ac.uk/pdbsum/6c9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c9t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q6N8V9_RHOPA Q6N8V9_RHOPA]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The MarR-family transcriptional regulator CouR, from the soil bacterium Rhodopseudomonas palustris CGA009, has recently been shown to negatively regulate a p-coumarate catabolic operon. Unlike most characterized MarR repressors that respond to small metabolites at concentrations in the millimolar range, repression by CouR is alleviated by the 800 Da ligand p-coumaroyl-CoA with high affinity and specificity. Here we report the crystal structures of ligand free CouR as well as the complex with p-coumaroyl-CoA, each to 2.1 A resolution, and the 2.85 A resolution cocrystal structure of CouR bound to an oligonucleotide bearing the cognate DNA operator sequence. In combination with binding experiments which uncover specific residues important for ligand and DNA recognition, these structures provide glimpses of a MarR family repressor in all possible states, allowing for an understanding for the molecular basis of DNA binding and the conformation alterations that accompany ligand-induced dissociation for activation of the operon.
-Authors: Cogan, D.P., Nair, S.K.
+Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism in Rhodopseudomonas palustris.,Cogan DP, Baraquet C, Harwood CS, Nair SK J Biol Chem. 2018 May 23. pii: RA118.003561. doi: 10.1074/jbc.RA118.003561. PMID:29794028<ref>PMID:29794028</ref>
-Description: Transcriptional repressor, CouR
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Nair, S.K]]
+<div class="pdbe-citations 6c9t" style="background-color:#fffaf0;"></div>
-[[Category: Cogan, D.P]]
+==See Also==
+*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rhodopseudomonas palustris CGA009]]
+[[Category: Cogan DP]]
+[[Category: Nair SK]]