6c9q: Difference between revisions

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<StructureSection load='6c9q' size='340' side='right'caption='[[6c9q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='6c9q' size='340' side='right'caption='[[6c9q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C9Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C9Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5N5:5-AMINO-5-DEOXYADENOSINE'>5N5</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">adoK, cbhK, MRA_2218 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5N5:5-AMINO-5-DEOXYADENOSINE'>5N5</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_kinase Adenosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c9q OCA], [https://pdbe.org/6c9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c9q RCSB], [https://www.ebi.ac.uk/pdbsum/6c9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c9q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c9q OCA], [http://pdbe.org/6c9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c9q RCSB], [http://www.ebi.ac.uk/pdbsum/6c9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c9q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ADOK_MYCTA ADOK_MYCTA]] Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP). Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to methyl-AMP, the first step in the metabolism of this compound to an active form that displays antitubercular activity. Is not active on guanosine, inosine, deoxyadenosine, cytidine, uridine, or thymidine. Prefers dGTP and GTP to ATP as phosphate donors in vitro.<ref>PMID:14594827</ref> 
[https://www.uniprot.org/uniprot/ADOK_MYCTU ADOK_MYCTU] ATP dependent phosphorylation of adenosine to monophosphate derivatives (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
<div class="pdbe-citations 6c9q" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c9q" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenosine kinase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Crespo, R A]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Structural genomic]]
[[Category: Crespo RA]]
[[Category: Complex]]
[[Category: Inhibitor]]
[[Category: Nucleoside analog]]
[[Category: PSI, Protein structure initiative]]
[[Category: Tbsgc]]
[[Category: Transferase-transferase inhibitor complex]]

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