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==CRYSTAL STRUCTURE OF Z-DNA WITH UNTYPICALLY COORDINATED CA2+ ION== | ==CRYSTAL STRUCTURE OF Z-DNA WITH UNTYPICALLY COORDINATED CA2+ ION== | ||
<StructureSection load='6bst' size='340' side='right' caption='[[6bst]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='6bst' size='340' side='right'caption='[[6bst]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6bst]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6b01 6b01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BST OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6bst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6b01 6b01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BST FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SR0:N~1~-(3-azaniumylpropyl)butane-1,4-diaminium'>SR0</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SR0:N~1~-(3-azaniumylpropyl)butane-1,4-diaminium'>SR0</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bst OCA], [https://pdbe.org/6bst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bst RCSB], [https://www.ebi.ac.uk/pdbsum/6bst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bst ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
DNA oligomer duplexes with alternating cytosines and guanines in their sequence tend to form helices of the Z-DNA type, where the sugar and phosphate backbone forms a left-handed helix in a zigzag fashion with a repeat of two successive Watson-Crick pairs of nucleotides. Z-DNA duplexes often crystallize in complexes with diverse metal ions interacting with polar DNA atoms in various ways. This work describes the high-resolution crystal structure of a Z-DNA d(CGCGCG)2 duplex in complex with Ca(2+) ions, unusually coordinated as an approximate pentagonal bipyramid by two neighboring guanines through their O6 and N7 atoms and a water molecule in the equatorial plane and a phosphate oxygen atom and another water molecule in the apical positions. | |||
The crystal structure of Z-DNA with untypically coordinated Ca(2+) ions.,Luo Z, Dauter Z J Biol Inorg Chem. 2017 Dec 21. pii: 10.1007/s00775-017-1526-4. doi:, 10.1007/s00775-017-1526-4. PMID:29270817<ref>PMID:29270817</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 6bst" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Z-DNA|Z-DNA]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: DAUTER Z]] | ||
[[Category: LUO Z]] | |||
[[Category: Z | |||