6ble: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 6ble is ON HOLD
+==Crystal Structure of the Human CAMKK2B in complex with CP673451==
+<StructureSection load='6ble' size='340' side='right'caption='[[6ble]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ble]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BLE FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34U:1-{2-[5-(2-METHOXYETHOXY)-1H-BENZIMIDAZOL-1-YL]QUINOLIN-8-YL}PIPERIDIN-4-AMINE'>34U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ble FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ble OCA], [https://pdbe.org/6ble PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ble RCSB], [https://www.ebi.ac.uk/pdbsum/6ble PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ble ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
-Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Structural Genomics Consortium (SGC), Elkins, J.M.
+==See Also==
+*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
-Description: Crystal Structure of the Human CAMKK2B in complex with CP673451
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Drewry, D]]
+__TOC__
-[[Category: Edwards, A.M]]
+</StructureSection>
-[[Category: Arruda, P]]
+[[Category: Homo sapiens]]
-[[Category: Massirer, K.B]]
+[[Category: Large Structures]]
-[[Category: Counago, R.M]]
+[[Category: Arruda P]]
-[[Category: Structural Genomics Consortium (Sgc), Elkins, J.M]]
+[[Category: Counago RM]]
-[[Category: Dos Reis, C.V]]
+[[Category: Drewry D]]
-[[Category: De Souza, G.P]]
+[[Category: Edwards AM]]
+[[Category: Elkins JM]]
+[[Category: Massirer KB]]
+[[Category: Ramos PZ]]
+[[Category: De Souza GP]]
+[[Category: Dos Reis CV]]