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==Structure of N-glycosylated porcine surfactant protein-D complexed with glycerol==
==Structure of N-glycosylated porcine surfactant protein-D complexed with glycerol==
<StructureSection load='6bbd' size='340' side='right' caption='[[6bbd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6bbd' size='340' side='right'caption='[[6bbd]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6bbd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBD FirstGlance]. <br>
<table><tr><td colspan='2'>[[6bbd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BBD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.898&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dn8|4dn8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbd OCA], [http://pdbe.org/6bbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bbd RCSB], [http://www.ebi.ac.uk/pdbsum/6bbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbd OCA], [https://pdbe.org/6bbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bbd RCSB], [https://www.ebi.ac.uk/pdbsum/6bbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SFTPD_PIG SFTPD_PIG]] Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).  
[https://www.uniprot.org/uniprot/SFTPD_PIG SFTPD_PIG] Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cafarella, T R]]
[[Category: Large Structures]]
[[Category: Die, I van]]
[[Category: Sus scrofa]]
[[Category: Eijk, M van]]
[[Category: Cafarella TR]]
[[Category: Haagsman, H P]]
[[Category: Haagsman HP]]
[[Category: Hartshorn, K L]]
[[Category: Hartshorn KL]]
[[Category: Hessing, M]]
[[Category: Hessing M]]
[[Category: Khatri, K]]
[[Category: Khatri K]]
[[Category: Leymarie, N]]
[[Category: Leymarie N]]
[[Category: Rynkiewicz, M J]]
[[Category: Rynkiewicz MJ]]
[[Category: Seaton, B A]]
[[Category: Seaton BA]]
[[Category: White, M R]]
[[Category: White MR]]
[[Category: Zaia, J]]
[[Category: Zaia J]]
[[Category: C-type lectin]]
[[Category: Van Die I]]
[[Category: Innate immunity]]
[[Category: Van Eijk M]]
[[Category: N-linked glycan]]
[[Category: Surfactant]]
[[Category: Surfactant protein]]

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