6aw5: Difference between revisions

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 ==1.90A resolution structure of catechol O-methyltransferase (COMT) L136M (hexagonal form) from Nannospalax galili==
-<StructureSection load='6aw5' size='340' side='right' caption='[[6aw5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='6aw5' size='340' side='right'caption='[[6aw5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6aw5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AW5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6aw5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw5 OCA], [http://pdbe.org/6aw5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aw5 RCSB], [http://www.ebi.ac.uk/pdbsum/6aw5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw5 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw5 OCA], [https://pdbe.org/6aw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw5 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw5 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A452CSQ2_NANGA A0A452CSQ2_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256]
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
 __TOC__
 </StructureSection>
-[[Category: Battaile, K P]]
+[[Category: Large Structures]]
-[[Category: Deng, Y]]
+[[Category: Nannospalax galili]]
-[[Category: Hanzlik, R P]]
+[[Category: Battaile KP]]
-[[Category: Lovell, S]]
+[[Category: Deng Y]]
-[[Category: Mehzabeen, N]]
+[[Category: Hanzlik RP]]
-[[Category: Moskovitz, J]]
+[[Category: Lovell S]]
-[[Category: Shams, I]]
+[[Category: Mehzabeen N]]
-[[Category: Comt]]
+[[Category: Moskovitz J]]
-[[Category: S-adenosylmethionine binding]]
+[[Category: Shams I]]
-[[Category: Spalax]]
-[[Category: Transferase]]