6asp: Difference between revisions

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OCA

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 ==Structure of Grp94 with methyl 3-chloro-2-(2-(1-(2-ethoxybenzyl)-1 H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, a Grp94-selective inhibitor and promising therapeutic lead for treating myocilin-associated glaucoma==
-<StructureSection load='6asp' size='340' side='right' caption='[[6asp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+<StructureSection load='6asp' size='340' side='right'caption='[[6asp]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6asp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ASP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ASP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6asp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ASP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ASP FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=V2C:methyl+3-chloro-2-(2-(1-(2-ethoxybenzyl)-1+H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate'>V2C</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.696&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6asp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6asp OCA], [http://pdbe.org/6asp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6asp RCSB], [http://www.ebi.ac.uk/pdbsum/6asp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6asp ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=V2C:methyl+3-chloro-2-(2-(1-(2-ethoxybenzyl)-1+H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate'>V2C</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6asp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6asp OCA], [https://pdbe.org/6asp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6asp RCSB], [https://www.ebi.ac.uk/pdbsum/6asp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6asp ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
+[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 6asp" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Huard, D J.E]]
+[[Category: Canis lupus familiaris]]
-[[Category: Lieberman, R L]]
+[[Category: Large Structures]]
-[[Category: Chaperone-inhibitor complex]]
+[[Category: Huard DJE]]
-[[Category: Glaucoma]]
+[[Category: Lieberman RL]]
-[[Category: Grp94]]
-[[Category: Hsp90]]
-[[Category: Inhibitor]]