5wl0: Difference between revisions

<table><tr><td colspan='2'>[[5wl0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WL0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WL0 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=21G:(2S,3S)-3-[[5-FLUORANYL-2-(5-FLUORANYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIMIDIN-4-YL]AMINO]BICYCLO[2.2.2]OCTANE-2-CARBOXYLIC+ACID'>21G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wl0 OCA], [http://pdbe.org/5wl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wl0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wl0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wl0 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PB2_I72A2 PB2_I72A2]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.  

[[Category: Ma, X]]

[[Category: Shia, S]]

[[Category: Viral protein-inhibitor complex]]