5w2q: Difference between revisions

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 ==Crystal structure of Mycobacterium tuberculosis KasA in complex with 6U5==
-<StructureSection load='5w2q' size='340' side='right' caption='[[5w2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='5w2q' size='340' side='right'caption='[[5w2q]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5w2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycte Mycte]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W2Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5w2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_str._Erdman_=_ATCC_35801 Mycobacterium tuberculosis str. Erdman = ATCC 35801]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W2Q FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6U5:~{N}-(1-METHYLINDAZOL-6-YL)BUTANE-1-SULFONAMIDE'>6U5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c72|4c72]], [[4c6w|4c6w]], [[4c70|4c70]], [[4c71|4c71]], [[4c73|4c73]], [[4c6z|4c6z]], [[2wge|2wge]], [[4c6x|4c6x]], [[2wgg|2wgg]], [[2wgd|2wgd]], [[5ld8|5ld8]], [[2wgf|2wgf]], [[4c6u|4c6u]], [[4c6v|4c6v]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6U5:~{N}-(1-METHYLINDAZOL-6-YL)BUTANE-1-SULFONAMIDE'>6U5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kasA, ERDMAN_2470 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=652616 MYCTE])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2q OCA], [https://pdbe.org/5w2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w2q RCSB], [https://www.ebi.ac.uk/pdbsum/5w2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2q ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w2q OCA], [http://pdbe.org/5w2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w2q RCSB], [http://www.ebi.ac.uk/pdbsum/5w2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w2q ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FAB1_MYCTE FAB1_MYCTE]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
+[https://www.uniprot.org/uniprot/KASA_MYCTU KASA_MYCTU] Part of the mycobacterial fatty acid elongation system FAS-II, which is involved in mycolic acid biosynthesis. Catalyzes the elongation of long chain acyl-ACP substrates by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:11600501, PubMed:12023885, PubMed:12464486, PubMed:16873379, PubMed:22017312, PubMed:24108128). Involved in the initial extension of the mycolate chain and forms monounsaturated fatty acids that averaged 40 carbons in length (PubMed:12464486).<ref>PMID:11600501</ref> <ref>PMID:12023885</ref> <ref>PMID:12464486</ref> <ref>PMID:16873379</ref> <ref>PMID:22017312</ref> <ref>PMID:24108128</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 19: @@
 </div>
 <div class="pdbe-citations 5w2q" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Mycte]]
+[[Category: Large Structures]]
-[[Category: Capodagli, G C]]
+[[Category: Mycobacterium tuberculosis str. Erdman = ATCC 35801]]
-[[Category: Neiditch, M B]]
+[[Category: Capodagli GC]]
-[[Category: Beta ketoacyl synthase i]]
+[[Category: Neiditch MB]]
-[[Category: Fatty acid biosynthesis]]
-[[Category: Lipid synthesis]]
-[[Category: Transferase]]