5uzu: Difference between revisions

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 ==Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase==
-<StructureSection load='5uzu' size='340' side='right' caption='[[5uzu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='5uzu' size='340' side='right'caption='[[5uzu]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5uzu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UZU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5uzu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UZU FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.403&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BN1321_100004, ERS072738_02531, ERS074020_02508, ERS140147_02483, HMPREF3211_00419 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885]), MPO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uzu OCA], [https://pdbe.org/5uzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uzu RCSB], [https://www.ebi.ac.uk/pdbsum/5uzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uzu ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myeloperoxidase Myeloperoxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.2.2 1.11.2.2] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uzu OCA], [http://pdbe.org/5uzu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uzu RCSB], [http://www.ebi.ac.uk/pdbsum/5uzu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uzu ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[http://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
+[https://www.uniprot.org/uniprot/Q2G0X2_STAA8 Q2G0X2_STAA8]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 19: @@
 </div>
 <div class="pdbe-citations 5uzu" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Myeloperoxidase|Myeloperoxidase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Myeloperoxidase]]
+[[Category: Large Structures]]
-[[Category: Fevre, C]]
+[[Category: Staphylococcus aureus]]
-[[Category: Garcia, B]]
+[[Category: Fevre C]]
-[[Category: Geisbrecht, B V]]
+[[Category: Garcia B]]
-[[Category: Guerra, F]]
+[[Category: Geisbrecht BV]]
-[[Category: Haas, P]]
+[[Category: Guerra F]]
-[[Category: Jong, N de]]
+[[Category: Haas P]]
-[[Category: Kessel, C van]]
+[[Category: Nijland R]]
-[[Category: Nijland, R]]
+[[Category: Ramyar K]]
-[[Category: Ramyar, K]]
+[[Category: Voyich-Kane J]]
-[[Category: Strijp, J van]]
+[[Category: De Jong N]]
-[[Category: Voyich-Kane, J]]
+[[Category: Van Kessel C]]
-[[Category: Oxidoreductase]]
+[[Category: Van Strijp J]]
-[[Category: Phagolysosome]]
-[[Category: Staphylococcal inhibitor innate immunity]]