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==Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090==
==Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090==
<StructureSection load='5upg' size='340' side='right' caption='[[5upg]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5upg' size='340' side='right'caption='[[5upg]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5upg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UPG FirstGlance]. <br>
<table><tr><td colspan='2'>[[5upg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UPG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8GJ:(2R)-4-[4-(2-FLUORO-4-METHOXYPHENYL)-2-OXOPYRIDIN-1(2H)-YL]-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)BUTANAMIDE'>8GJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-acyl-N-acetylglucosamine_deacetylase UDP-3-O-acyl-N-acetylglucosamine deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.108 3.5.1.108] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8GJ:(2R)-4-[4-(2-FLUORO-4-METHOXYPHENYL)-2-OXOPYRIDIN-1(2H)-YL]-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)BUTANAMIDE'>8GJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5upg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upg OCA], [http://pdbe.org/5upg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5upg RCSB], [http://www.ebi.ac.uk/pdbsum/5upg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5upg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5upg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upg OCA], [https://pdbe.org/5upg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5upg RCSB], [https://www.ebi.ac.uk/pdbsum/5upg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5upg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.  
[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
==See Also==
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Hydrolase]]
[[Category: Lipid a biosynthesis]]
[[Category: Lpxc]]
[[Category: Pf-5081090]]
[[Category: Ssgcid]]
[[Category: Udp-3-o-acyl-n-acetylglucosamine deacetylase]]

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