5uml: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 5uml is ON HOLD  until Paper Publication
+==CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3==
+<StructureSection load='5uml' size='340' side='right'caption='[[5uml]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5uml]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UML FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uml OCA], [https://pdbe.org/5uml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uml RCSB], [https://www.ebi.ac.uk/pdbsum/5uml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uml ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
-Authors: Marzena, P., Neelakshi, G., William, T.
+==See Also==
+*[[MDM4|MDM4]]
-Description: CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: William, T]]
+__TOC__
-[[Category: Neelakshi, G]]
+</StructureSection>
-[[Category: Marzena, P]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Synthetic construct]]
+[[Category: Gohain N]]
+[[Category: Pazgier M]]
+[[Category: Tolbert WD]]