5u11: Difference between revisions

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 ==E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]-N-methylacetamide==
-<StructureSection load='5u11' size='340' side='right' caption='[[5u11]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
+<StructureSection load='5u11' size='340' side='right'caption='[[5u11]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5u11]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U11 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5u11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U11 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7PS:2-[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]-N-methylacetamide'>7PS</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.994&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u0v|5u0v]], [[5u0w|5u0w]], [[5u0x|5u0x]], [[5u0y|5u0y]], [[5u0z|5u0z]], [[5u10|5u10]], [[5u12|5u12]], [[5u13|5u13]], [[5u14|5u14]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PS:2-[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]-N-methylacetamide'>7PS</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u11 OCA], [https://pdbe.org/5u11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u11 RCSB], [https://www.ebi.ac.uk/pdbsum/5u11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u11 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u11 OCA], [http://pdbe.org/5u11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u11 RCSB], [http://www.ebi.ac.uk/pdbsum/5u11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u11 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DHPS_ECOL6 DHPS_ECOL6]] Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.[UniProtKB:P0AC13]
+[https://www.uniprot.org/uniprot/DHPS_ECOLI DHPS_ECOLI] DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.<ref>PMID:368012</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 </div>
 <div class="pdbe-citations 5u11" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Dihydropteroate synthase]]
+[[Category: Escherichia coli CFT073]]
-[[Category: Dennis, M L]]
+[[Category: Large Structures]]
-[[Category: Peat, T S]]
+[[Category: Dennis ML]]
-[[Category: Swarbrick, J D]]
+[[Category: Peat TS]]
-[[Category: Complex]]
+[[Category: Swarbrick JD]]
-[[Category: Dhp]]
-[[Category: E. coli]]
-[[Category: Pterin site]]
-[[Category: Transferase-transferase inhibitor complex]]