8h0o: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 8h0o is ON HOLD  until Paper Publication
+==Crystal structure of human serum albumin and ruthenium PZA complex adduct==
+<StructureSection load='8h0o' size='340' side='right'caption='[[8h0o]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-Authors: Gong, W.J., Wang, Y., Bai, H.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8h0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H0O FirstGlance]. <br>
-Description: Crystal structure of human serum albumin and ruthenium complex adduct
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.479&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NO:NITRIC+OXIDE'>NO</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PZA:PYRAZINE-2-CARBOXAMIDE'>PZA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
-[[Category: Wang, Y]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h0o OCA], [https://pdbe.org/8h0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h0o RCSB], [https://www.ebi.ac.uk/pdbsum/8h0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h0o ProSAT]</span></td></tr>
-[[Category: Bai, H.H]]
+</table>
-[[Category: Gong, W.J]]
+== Disease ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Bai HH]]
+[[Category: Gong WJ]]
+[[Category: Wang HF]]
+[[Category: Wang WM]]
+[[Category: Wang Y]]