Pyruvate-ferredoxin oxidoreductase: Difference between revisions
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< | <StructureSection load='2c3o' size='350' side='right' scene='49/490113/Cv/1' caption='Pyruvate-ferredoxin oxidoredoxin dimer with Fe4S4 cluster complex with thiamine diphosphate and pyruvate [[2c3o]]'> | ||
''' | |||
== Function == | |||
'''Pyruvate-ferredoxin oxidoreductase''' (PFOR) is an enzyme of the fermentation cycle which catalyzes the oxidative decarboxylation of pyruvate to acetyl CoA and CO<sub>2</sub>. This reaction provides the electron source for the reduction of ferredoxin<ref>PMID:10878009</ref>. The reaction is CoA-dependent and contains thiamine diphosphate (TDP). PFOR contains iron-sulfur clusters (Fe<sub>4</sub>S<sub>4</sub>). | |||
== Structural highlights == | |||
The <scene name='49/490113/Cv/6'>active site of PFOR contains thiamine diphosphate and pyruvate</scene><ref>PMID:16472741</ref>. <scene name='49/490113/Cv/7'>Mg coordination site</scene>. Water molecules are shown as red spheres. <scene name='49/490113/Cv/8'>Fe4S4 cluster interactions</scene>. Each Fe atom interacts with S atom from cysteine. | |||
</StructureSection> | |||
==3D structures of pyruvate-ferredoxin oxidoreductase== | ==3D structures of pyruvate-ferredoxin oxidoreductase== | ||
{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1b0p]], [[2c3m]] – DaPFOR + TDP – ''Desulfovibrio africanus''<br /> | [[1b0p]], [[2c3m]] – DaPFOR + TDP – ''Desulfovibrio africanus''<br /> | ||
[[2pda]], [[2c3o]], [[2c42]] - DaPFOR + pyruvate + TDP<br /> | [[2pda]], [[2c3o]], [[2c42]] - DaPFOR + pyruvate + TDP<br /> | ||
[[1kek]], [[2c3y]] - DaPFOR + CO2 + acetyl-TDP<br /> | [[1kek]], [[2c3y]], [[2uza]] - DaPFOR + CO2 + acetyl-TDP<br /> | ||
[[2c3p]] - DaPFOR + TDP derivative<br /> | [[2c3p]] - DaPFOR + TDP derivative<br /> | ||
[[2c3u]] - DaPFOR + pyruvate + TDP derivative | [[2c3u]] - DaPFOR + pyruvate + TDP derivative<br /> | ||
[[7plm]] – DaPFOR + TPP – Cryo EM<br /> | |||
[[2raa]] - PFOR γ subunit - ''Thermotoga maritima''<br /> | |||
[[6cin]] – MtPFOR + TDP – ''Moorella thermoacetica''<br /> | |||
[[6cio]], [[6cip]] – MtPFOR + TTP derivative <br /> | |||
[[6ciq]] – MtPFOR + TTP + CoA <br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||