5ksw: Difference between revisions

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==DHODB-I74D mutant==
==DHODB-I74D mutant==
<StructureSection load='5ksw' size='340' side='right' caption='[[5ksw]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='5ksw' size='340' side='right'caption='[[5ksw]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ksw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KSW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ksw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis] and [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KSW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(NAD(+)) Dihydroorotate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.14 1.3.1.14] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ksw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksw OCA], [http://pdbe.org/5ksw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ksw RCSB], [http://www.ebi.ac.uk/pdbsum/5ksw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ksw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ksw OCA], [https://pdbe.org/5ksw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ksw RCSB], [https://www.ebi.ac.uk/pdbsum/5ksw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ksw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A089ZD72_9LACT A0A089ZD72_9LACT]] Catalyzes the conversion of dihydroorotate to orotate.[HAMAP-Rule:MF_00224][SAAS:SAAS00570238] [[http://www.uniprot.org/uniprot/A0A0V8EGX5_LACLL A0A0V8EGX5_LACLL]] Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).[HAMAP-Rule:MF_01211]  
[https://www.uniprot.org/uniprot/PYRDB_LACLA PYRDB_LACLA] Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
 
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pompeu, Y A]]
[[Category: Lactococcus lactis]]
[[Category: Stewart, J D]]
[[Category: Lactococcus lactis subsp. lactis]]
[[Category: Dehydrogenase]]
[[Category: Large Structures]]
[[Category: Electron transfer]]
[[Category: Pompeu YA]]
[[Category: Orotate]]
[[Category: Stewart JD]]
[[Category: Oxidoreductase]]
[[Category: Protein engineering]]
[[Category: Pyrimidine bisynthesis fes cluster]]
[[Category: Reductase]]

Latest revision as of 13:53, 27 September 2023

DHODB-I74D mutantDHODB-I74D mutant

Structural highlights

5ksw is a 4 chain structure with sequence from Lactococcus lactis and Lactococcus lactis subsp. lactis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.47Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PYRDB_LACLA Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.

See Also

5ksw, resolution 2.47Å

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