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==High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine== | ==High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine== | ||
<StructureSection load='5kb6' size='340' side='right' caption='[[5kb6]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='5kb6' size='340' side='right'caption='[[5kb6]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5kb6]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5kb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KB6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb6 OCA], [https://pdbe.org/5kb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kb6 RCSB], [https://www.ebi.ac.uk/pdbsum/5kb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb6 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ADK_MOUSE ADK_MOUSE] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. | ||
==See Also== | |||
*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Franchini | [[Category: Franchini KG]] | ||
[[Category: Murakami | [[Category: Murakami MT]] | ||
[[Category: Neto | [[Category: Neto RM]] | ||
[[Category: Oliveira | [[Category: Oliveira RR]] | ||
[[Category: Polo | [[Category: Polo CC]] | ||
[[Category: Tonoli | [[Category: Tonoli CCC]] | ||
Latest revision as of 13:44, 27 September 2023
High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosineHigh-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine
Structural highlights
FunctionADK_MOUSE ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. See Also |
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