5k5s: Difference between revisions

<StructureSection load='5k5s' size='340' side='right' caption='[[5k5s]], [[Resolution|resolution]] 2.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[5k5s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K5S FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5k5t|5k5t]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k5s OCA], [http://pdbe.org/5k5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k5s RCSB], [http://www.ebi.ac.uk/pdbsum/5k5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k5s ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN]] Autosomal dominant hypocalcemia;Familial isolated hypoparathyroidism due to impaired PTH secretion;Neonatal severe primary hyperparathyroidism;Familial hypocalciuric hypercalcemia type 1;Bartter syndrome with hypocalcemia. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations.  

[[http://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN]] Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.  

[[Category: Brennan, S C]]

[[Category: Brown, A P]]

[[Category: Bush, M]]

[[Category: Cao, B]]

[[Category: Chang, D]]

[[Category: Chen, Y]]

[[Category: Cheng, T C]]

[[Category: Colecraft, H M]]

[[Category: Conigrave, A]]

[[Category: Fan, Q R]]

[[Category: Geng, Y]]

[[Category: Kurinov, I]]

[[Category: McDonald, P]]

[[Category: Mosyak, L]]

[[Category: Mun, H C]]

[[Category: Nguyen, T]]

[[Category: Quick, M]]

[[Category: Sturchler, E]]

[[Category: Subramanyam, P]]

[[Category: Zuo, H]]

[[Category: Venus flytrap module]]