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==Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex==
==Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex==
<StructureSection load='5kmc' size='340' side='right' caption='[[5kmc]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='5kmc' size='340' side='right'caption='[[5kmc]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kmc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KMC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kmc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KMC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6UU:[2-(1~{H}-indol-3-yl)ethylamino]phosphonic+acid'>6UU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[5ipb|5ipb]], [[5ipc|5ipc]], [[5ipd|5ipd]], [[5ipe|5ipe]], [[5kly|5kly]], [[5klz|5klz]], [[5km0|5km0]], [[5km1|5km1]], [[5km2|5km2]], [[5km3|5km3]], [[5km4|5km4]], [[5km5|5km5]], [[5km6|5km6]], [[5km7|5km7]], [[5km8|5km8]], [[5km9|5km9]], [[5kma|5kma]], [[5kmb|5kmb]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6UU:[2-(1~{H}-indol-3-yl)ethylamino]phosphonic+acid'>6UU</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HINT1, HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmc OCA], [https://pdbe.org/5kmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kmc RCSB], [https://www.ebi.ac.uk/pdbsum/5kmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kmc OCA], [http://pdbe.org/5kmc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kmc RCSB], [http://www.ebi.ac.uk/pdbsum/5kmc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kmc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).  
[https://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
 
==See Also==
*[[Histidine triad nucleotide-binding protein 3D structures|Histidine triad nucleotide-binding protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Finzel, B C]]
[[Category: Large Structures]]
[[Category: Maize, K M]]
[[Category: Finzel BC]]
[[Category: Hint]]
[[Category: Maize KM]]
[[Category: Histidine triad]]
[[Category: Hit]]
[[Category: Hydrolase]]

Latest revision as of 13:03, 27 September 2023

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complexHuman Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex

Structural highlights

5kmc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.35Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HINT1_HUMAN Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).

See Also

5kmc, resolution 1.35Å

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