5kjk: Difference between revisions

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 ==SMYD2 in complex with AZ370==
-<StructureSection load='5kjk' size='340' side='right' caption='[[5kjk]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
+<StructureSection load='5kjk' size='340' side='right'caption='[[5kjk]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5kjk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJK FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5kjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KJK FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T1:2-[2-[1-[2-(3,4-DICHLOROPHENYL)ETHYL]AZETIDIN-3-YL]OXYPHENYL]-~{N}-(3-PYRROLIDIN-1-YLPROPYL)PYRIDINE-4-CARBOXAMIDE'>6T1</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kjl|5kjl]], [[5kjm|5kjm]], [[5kjn|5kjn]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6T1:2-[2-[1-[2-(3,4-DICHLOROPHENYL)ETHYL]AZETIDIN-3-YL]OXYPHENYL]-~{N}-(3-PYRROLIDIN-1-YLPROPYL)PYRIDINE-4-CARBOXAMIDE'>6T1</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjk OCA], [http://pdbe.org/5kjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kjk RCSB], [http://www.ebi.ac.uk/pdbsum/5kjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjk ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjk OCA], [https://pdbe.org/5kjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kjk RCSB], [https://www.ebi.ac.uk/pdbsum/5kjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjk ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
+[https://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 5kjk" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ferguson, A]]
+[[Category: Homo sapiens]]
-[[Category: Histone methyltransferase]]
+[[Category: Large Structures]]
-[[Category: Inhibitor]]
+[[Category: Ferguson A]]
-[[Category: Smyd2]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase inhibitor complex]]