5kea: Difference between revisions

==mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form I==

<StructureSection load='5kea' size='340' side='right'caption='[[5kea]], [[Resolution|resolution]] 2.46&Aring;' scene=''>

<table><tr><td colspan='2'>[[5kea]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KEA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.458&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kea OCA], [https://pdbe.org/5kea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kea RCSB], [https://www.ebi.ac.uk/pdbsum/5kea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kea ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Synthetic construct]]

[[Category: Cheng X]]

[[Category: Hashimoto H]]