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==Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element==
==Structural Studies of Transcription Factor p73 DNA Binding Domain Bound to PA26 20-mer Response Element==
<StructureSection load='5kbd' size='340' side='right' caption='[[5kbd]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5kbd' size='340' side='right'caption='[[5kbd]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kbd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KBD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KBD FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kbd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KBD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kd3|5kd3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kbd OCA], [http://pdbe.org/5kbd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kbd RCSB], [http://www.ebi.ac.uk/pdbsum/5kbd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kbd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kbd OCA], [https://pdbe.org/5kbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kbd RCSB], [https://www.ebi.ac.uk/pdbsum/5kbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kbd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>  
 
==See Also==
*[[P73|P73]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Huang, D]]
[[Category: Homo sapiens]]
[[Category: Nguyen, H T]]
[[Category: Large Structures]]
[[Category: Dna binding protein-dna complex]]
[[Category: Huang D]]
[[Category: Tumor suppressor transcription factor p53 response element]]
[[Category: Nguyen HT]]

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