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==Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate==
==Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate==
<StructureSection load='5kb5' size='340' side='right' caption='[[5kb5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5kb5' size='340' side='right'caption='[[5kb5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5kb5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KB5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5kb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KB5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kb6|5kb6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_kinase Adenosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb5 OCA], [https://pdbe.org/5kb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kb5 RCSB], [https://www.ebi.ac.uk/pdbsum/5kb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kb5 OCA], [http://pdbe.org/5kb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kb5 RCSB], [http://www.ebi.ac.uk/pdbsum/5kb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kb5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ADK_MOUSE ADK_MOUSE]] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.  
[https://www.uniprot.org/uniprot/ADK_MOUSE ADK_MOUSE] ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
 
==See Also==
*[[Adenosine kinase 3D structures|Adenosine kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenosine kinase]]
[[Category: Large Structures]]
[[Category: Franchini, K G]]
[[Category: Mus musculus]]
[[Category: Murakami, M T]]
[[Category: Franchini KG]]
[[Category: Neto, R M]]
[[Category: Murakami MT]]
[[Category: Oliveira, R R]]
[[Category: Neto RM]]
[[Category: Polo, C C]]
[[Category: Oliveira RR]]
[[Category: Tonoli, C C.C]]
[[Category: Polo CC]]
[[Category: Transferase]]
[[Category: Tonoli CCC]]

Latest revision as of 12:57, 27 September 2023

Crystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphateCrystal structure of the adenosine kinase from Mus musculus in complex with adenosine and adenosine-diphosphate

Structural highlights

5kb5 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:, , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADK_MOUSE ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

See Also

5kb5, resolution 1.80Å

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