5cxw: Difference between revisions

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 ==Structure of the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V==
-<StructureSection load='5cxw' size='340' side='right' caption='[[5cxw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+<StructureSection load='5cxw' size='340' side='right'caption='[[5cxw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5cxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5cxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CXW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=35P:(2R,4S)-5,5-DIMETHYL-2-{(1R)-2-OXO-1-[(PHENOXYACETYL)AMINO]ETHYL}-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>35P</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5crf|5crf]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=35P:(2R,4S)-5,5-DIMETHYL-2-{(1R)-2-OXO-1-[(PHENOXYACETYL)AMINO]ETHYL}-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>35P</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxw OCA], [http://pdbe.org/5cxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxw RCSB], [http://www.ebi.ac.uk/pdbsum/5cxw PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxw OCA], [https://pdbe.org/5cxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cxw RCSB], [https://www.ebi.ac.uk/pdbsum/5cxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cxw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PBP1A_MYCTU PBP1A_MYCTU]] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Has little peptidoglycan hydrolytic activity; however it inhibits the synergistic peptidoglycan hydrolysis of RipA plus RpfB.<ref>PMID:20686708</ref>
+[https://www.uniprot.org/uniprot/PBP1A_MYCTU PBP1A_MYCTU] Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity). Has little peptidoglycan hydrolytic activity; however it inhibits the synergistic peptidoglycan hydrolysis of RipA plus RpfB.<ref>PMID:20686708</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 5cxw" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Anderson, W F]]
+[[Category: Large Structures]]
-[[Category: Endres, M]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Filippova, E V]]
+[[Category: Anderson WF]]
-[[Category: Joachimiak, A]]
+[[Category: Endres M]]
-[[Category: Kieser, K]]
+[[Category: Filippova EV]]
-[[Category: Kiryukhina, O]]
+[[Category: Joachimiak A]]
-[[Category: Structural genomic]]
+[[Category: Kieser K]]
-[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
+[[Category: Kiryukhina O]]
-[[Category: Rubin, E]]
+[[Category: Rubin E]]
-[[Category: Sacchettini, J]]
+[[Category: Sacchettini J]]
-[[Category: B-lactam]]
-[[Category: Mcsg]]
-[[Category: Mtbi]]
-[[Category: Pbp]]
-[[Category: Penicillin-binding protein-antibiotic complex]]
-[[Category: Psi-biology]]
-[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]