4zvu: Difference between revisions

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 ==Caspase-7 wild-type bound to the caspase-6 cognate tetrapeptide inhibitor Ac-VEID-cho==
-<StructureSection load='4zvu' size='340' side='right' caption='[[4zvu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='4zvu' size='340' side='right'caption='[[4zvu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4zvu]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4zvu]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZVU FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.601&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zvs|4zvs]], [[4zvt|4zvt]], [[4zvq|4zvq]], [[4zvp|4zvp]], [[4zvo|4zvo]], [[4zvr|4zvr]], [[1f1j|1f1j]], [[3edr|3edr]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvu OCA], [https://pdbe.org/4zvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zvu RCSB], [https://www.ebi.ac.uk/pdbsum/4zvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvu ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvu OCA], [http://pdbe.org/4zvu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvu RCSB], [http://www.ebi.ac.uk/pdbsum/4zvu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
+[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 </div>
 <div class="pdbe-citations 4zvu" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Caspase-7]]
+[[Category: Homo sapiens]]
-[[Category: Hardy, J A]]
+[[Category: Large Structures]]
-[[Category: Hill, M E]]
+[[Category: Synthetic construct]]
-[[Category: MacPherson, D J]]
+[[Category: Hardy JA]]
-[[Category: Designed active site specificity]]
+[[Category: Hill ME]]
-[[Category: Directed evolution]]
+[[Category: MacPherson DJ]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Peptide inhibitor]]
-[[Category: Protease]]