4zt2: Difference between revisions

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==Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575)==
==Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor N-(3,5-dichlorobenzyl)-N'-(1H-imidazo[4,5-b]pyridin-2-yl)propane-1,3-diamine (Chem 1575)==
<StructureSection load='4zt2' size='340' side='right' caption='[[4zt2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4zt2' size='340' side='right'caption='[[4zt2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zt2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZT2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZT2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4RP:N-(3,5-DICHLOROBENZYL)-N-(1H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PROPANE-1,3-DIAMINE'>4RP</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4RP:N-(3,5-DICHLOROBENZYL)-N-(1H-IMIDAZO[4,5-B]PYRIDIN-2-YL)PROPANE-1,3-DIAMINE'>4RP</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zt6|4zt6]], [[4zt5|4zt5]], [[4zt4|4zt4]], [[4zt3|4zt3]], [[4zt7|4zt7]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zt2 OCA], [https://pdbe.org/4zt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zt2 RCSB], [https://www.ebi.ac.uk/pdbsum/4zt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zt2 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zt2 OCA], [http://pdbe.org/4zt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4zt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zt2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zt2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zt2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methionine--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Hol, W G.J]]
[[Category: Trypanosoma brucei brucei TREU927]]
[[Category: Koh, C Y]]
[[Category: Hol WGJ]]
[[Category: Aar]]
[[Category: Koh C-Y]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Ligase]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Metr]]
[[Category: Protein-inhibitor complex]]
[[Category: Trypanosoma brucei]]

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