4z0l: Difference between revisions
New page: '''Unreleased structure''' The entry 4z0l is ON HOLD Authors: Xu, S., Neumann, W., Banerjee, S., Hey-Hawkins, E., Marnett, L.J. Description: The murine cyclooxygenase-2 complexed with ... |
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The | ==The murine cyclooxygenase-2 complexed with a nido-dicarbaborate-containing indomethacin derivative== | ||
<StructureSection load='4z0l' size='340' side='right'caption='[[4z0l]], [[Resolution|resolution]] 2.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4z0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z0L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LA:(R)-7-{[5-METHOXY-2-METHYL-3-(METHOXYCARBONYLMETHYL)-1H-INDOLYL]CARBONYL}-7,8-DICARBA-NIDO-DODECA-HYDROUNDECABORATE'>4LA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=N1B:(S)-7-{[5-METHOXY-2-METHYL-3-(METHOXYCARBONYLMETHYL)-1H-INDOLYL]CARBONYL}-7,8-DICARBA-NIDO-DODECA-HYDROUNDECABORATE'>N1B</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0l OCA], [https://pdbe.org/4z0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z0l RCSB], [https://www.ebi.ac.uk/pdbsum/4z0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Carbaboranes are increasingly studied as pharmacophores, particularly as replacements for aromatic systems. However, especially ortho-carbaborane is prone to degradation of the cluster, which hampers biological application. This study demonstrates that deboronation of the cluster may not only lead to a more active analogue, but can also improve the solubility and stability of a carbaborane-containing inhibitor. Notably, introduction of a nido-dicarbaborate cluster into the cyclooxygenase (COX) inhibitor indomethacin results in remarkably increased inhibitory potency and selectivity for COX-2 relative to the respective phenyl analogue. The first crystal structure of a carbaborane-containing inhibitor bound to COX-2 further reveals a novel binding mode for the inhibitor that is strikingly different from that of indomethacin. These results indicate that nido-dicarbaborate is a promising pharmacophore that exhibits properties which are also highly beneficial for its introduction into other inhibitor classes. | |||
nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.,Neumann W, Xu S, Sarosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins HC ChemMedChem. 2015 Jun 18. doi: 10.1002/cmdc.201500199. PMID:26088701<ref>PMID:26088701</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 4z0l" style="background-color:#fffaf0;"></div> | ||
[[Category: Banerjee | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Cyclooxygenase 3D structures|Cyclooxygenase 3D structures]] | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Banerjee S]] | |||
[[Category: Hey-Hawkins E]] | |||
[[Category: Marnett LJ]] | |||
[[Category: Neumann W]] | |||
[[Category: Xu S]] | |||