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==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
==Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds==
<StructureSection load='4yql' size='340' side='right' caption='[[4yql]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4yql' size='340' side='right'caption='[[4yql]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yql]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yql]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4H4:4-AMINO-N-[(1S,2R)-2-(4-SULFAMOYLPHENYL)CYCLOPROPYL]-1,2,5-OXADIAZOLE-3-CARBOXAMIDE'>4H4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.401&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ypw|4ypw]], [[4ypx|4ypx]], [[4ypz|4ypz]], [[4yq0|4yq0]], [[4yq1|4yq1]], [[4yq2|4yq2]], [[4yq3|4yq3]], [[4yq4|4yq4]], [[4yq5|4yq5]], [[4yq6|4yq6]], [[4yq7|4yq7]], [[4yq8|4yq8]], [[4yq9|4yq9]], [[4yqa|4yqa]], [[4yqb|4yqb]], [[4yqc|4yqc]], [[4yqg|4yqg]], [[4yqi|4yqi]], [[4yqj|4yqj]], [[4yqk|4yqk]], [[4yqn|4yqn]], [[4yqo|4yqo]], [[4yqp|4yqp]], [[4yqq|4yqq]], [[4yqr|4yqr]], [[4yqs|4yqs]], [[4yqt|4yqt]], [[4ypy|4ypy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4H4:4-AMINO-N-[(1S,2R)-2-(4-SULFAMOYLPHENYL)CYCLOPROPYL]-1,2,5-OXADIAZOLE-3-CARBOXAMIDE'>4H4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA_(guanine(37)-N(1))-methyltransferase tRNA (guanine(37)-N(1))-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.228 2.1.1.228] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yql OCA], [https://pdbe.org/4yql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yql RCSB], [https://www.ebi.ac.uk/pdbsum/4yql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yql ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yql OCA], [http://pdbe.org/4yql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yql RCSB], [http://www.ebi.ac.uk/pdbsum/4yql PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN]] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]  
[https://www.uniprot.org/uniprot/TRMD_HAEIN TRMD_HAEIN] Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]
 
==See Also==
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bonnette, W G]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Elkins, P A]]
[[Category: Large Structures]]
[[Category: Madauss, K P]]
[[Category: Bonnette WG]]
[[Category: Knot]]
[[Category: Elkins PA]]
[[Category: Sam-binding]]
[[Category: Madauss KP]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Trmd]]

Latest revision as of 11:04, 27 September 2023

Crystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compoundsCrystal structure of TrmD, a M1G37 tRNA Methyltransferase with SAM-competitive compounds

Structural highlights

4yql is a 1 chain structure with sequence from Haemophilus influenzae Rd KW20. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.401Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRMD_HAEIN Specifically methylates guanosine-37 in various tRNAs (By similarity).[HAMAP-Rule:MF_00605]

See Also

4yql, resolution 2.40Å

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